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sildenafil 63 articles

Is erectile dysfunction only a problem for aging men?

Men’s Health reports that erectile dysfunction (ED) is not just a problem for older men, and one startup business is marketing and selling sildenafil, the active ingredient in Viagra, to younger guys in their 20s and 30s. Besides sildenafil, Hims sells a variety of products for hair and skin, addressing issues such as male pattern baldness and adult acne. According to its website, the Hims Mission is to “create an open and empowered male culture that results in more proactivity around health and preventative self-care.” “The fact that you’re struggling with [erectile dysfunction] has no reflection on you as a ... Read More

Don’t delay melanoma treatment, prompt surgery saves lives, research shows

According to U.S. News and World Report, researchers with the Cleveland Clinic have found that delaying treatment of melanoma even one month reduces a patient’s chance of survival. Melanoma is the most deadly form of skin cancer, on average, killing one American an hour. “The ideal timing for melanoma treatment, predominantly surgery, had yet to be determined — until now,” said primary investigator Dr. Brian Gastman. He is director of melanoma surgery at the Cleveland Clinic in Ohio. Gastman and colleagues used the National Cancer Database to identify and study the data of 153,218 adult patients who were diagnosed with ... Read More

Research suggests potential new drug treatment for erectile dysfunction

Researchers in Ireland have found a potential new strategy for treating erectile dysfunction (ED). Their findings were published in American Journal of Physiology-Cell Physiology, according to Medical Xpress. Researchers from the Smooth Muscle Research Centre at the Dundalk Institute of Technology, in Dundalk, Ireland, knowing that the movement of negatively charged chloride through the erectile tissue causes muscle contraction that inhibits erection, decided to study two chloride channel-blocking drugs. In animal studies they found that both of these drugs were able to block the flow of chloride. Because of this the smooth muscle cells relaxed, which is necessary for erection. ... Read More

Viagra may harm patients with residual pulmonary hypertension

Researchers have been surprised to discover that Viagra, or sildenafil, which is commonly prescribed off-label to treat retrograde pulmonary hypertension, may actually be harmful to these patients, increasing risk of hospitalization and other negative clinical outcomes. The Spanish researchers studied 200 patients in 17 hospitals who had residual pulmonary hypertension after correction of a valvular lesion. They were randomly divided into two groups, one given 40 mg of sildenafil three times a day for six months, the other a placebo for the same amount of time. The researchers tracked deaths, hospital admissions for heart failure, tolerance for physical activity, and ... Read More

FDA, health agencies address pediatric heart research

In 2012 the U.S. Food and Drug Administration (FDA) issued a recommendation that sildenafil should not be prescribed to children (ages 1 through 17) for pulmonary arterial hypertension (PAH). This recommendation followed the conclusion of two pediatric clinical trials that lasted from 2003-2011 studying 234 children ages 1 to 17.  According to the American Heart Association, the trials found children taking higher doses had a higher risk of death than those taking lower doses, and lower doses were not effective. Since that time, the same drugs have also been linked to the dangerous side effect of increasing risk of developing melanoma, the ... Read More

Know melanoma warning signs and risk factors

Today is the last day of Melanoma Awareness Month. For the month of May, advocates have been doing what they can to fight the most deadly skin cancer, which is one of the most common cancers diagnosed in the United States, with incidence on the rise, according to the Melanoma Research Alliance. Nearly 10,000 people in the United States are expected to die of melanoma in 2017. Early identification and prevention of melanoma are keys to education initiatives, as survival rates for late-stage melanoma are low in spite of ongoing research to improve understanding of the disease and its treatment. ... Read More

Pfizer seeks to expand Viagra sales to over-the-counter

According to the Pharmaceutical Journal, Pfizer, the manufacturer of erectile dysfunction (ED) drug Viagra (sildenafil) has set its sights on having the drug, which has been prescribed for more than 64 million men worldwide, available over-the-counter as well. Ten years ago Pfizer applied to the European Medicines Agency (EMA) for non-prescription status of Viagra, but the agency had concerns that in bypassing the need for a prescription from a general practitioner (GP), men whose symptoms would have led to diagnosis of cardiovascular disease might self-diagnose and treat ED symptoms over-the-counter, missing the underlying more serious disease. The agency also expressed ... Read More

Will Viagra become available in the UK without a prescription?

According to BT.com in the UK, plans have been unveiled for eliminating the need for a prescription for Viagra and instead men would be able to purchase the drug legally “after a chat with a pharmacist.” The Medicines and Healthcare products Regulatory Agency (MHRA) is reviewing the proposal to make Viagra over-the-counter during a consultation that runs until April 17. An MHRA spokesman said: “We always aim to widen choice and access for medicines when it is safe to do so. A final decision on whether to make sildenafil 50mg tablets available as a pharmacy medicine has yet to be made. ... Read More

Dietary supplements promoted for sexual enhancement found to include undeclared drug

The Food and Drug Administration (FDA) is warning consumers not to purchase or use certain dietary supplements promoted for sexual enhancement because laboratory analyses found the products to contain a hidden drug ingredient that can be life threatening to some consumers. The FDA singled out five dietary supplement this week during an examination of international shipments. They include: Rhino 8 Platinum 8000 Rhino 7K 9000 Male Performance Booster Power Male Sexual Stimulant Black 3K Plus Male Sexual Enhancement Capsules African Viagra All the products are promoted for male sexual enhancement and all were found to contain sildenafil, the active ingredient ... Read More

Does sildenafil help patients with diastolic heart failure?

Sildenafil, the active ingredient in Viagra, a phosphodiesterase-5 inhibitor (PDE5 inhibitor), is not only an erectile dysfunction drug. It is also approved to treat pulmonary artery hypertension, a complication that can worsen the prognosis for patients who have heart failure with preserved ejection fraction (HFpEF), also referred to as diastolic heart failure. Approximately half of people with heart failure have HFpEF. Researchers from The Wright Center for Graduate Medical Education, Scranton, Pennsylvania, recently conducted a meta-analysis to determine the efficacy of sildenafil specifically on the hemodynamic parameters in patients with HFpEF. They identified only four randomized controlled studies with a ... Read More