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simvastatin 15 articles

Type 2 diabetes added to list of statin side effects

Cholesterol-lowering statin drugs are widely prescribed to lower levels of LDL – the so-called “bad” cholesterol – that builds up in the arteries in order to prevent cardiovascular events. However, studies have found the drugs can increase blood sugar levels and put users at risk of developing type 2 diabetes. Statins work by preventing the liver from producing LDL cholesterol. They also stabilize the lining of the blood vessels, which helps to prevent strokes and heart attacks. How statins effect glucose metabolism is unclear. Some studies suggest that statins may cause hyperglycemia – or high blood sugar – by increasing ... Read More

FDA rejects consumer group’s request for black box warning on statin drugs

Cholesterol-lowering statin medication will not carry a black box warning for a deadly muscle disorder, the Food and Drug Administration (FDA) announced. The agency was petitioned by the consumer watchdog group Public Citizen, urging the FDA to force drug makers to alert consumers of the risk of rhambdomyolysis, a condition in which muscle cells break down and enter the bloodstream where they can damage the kidneys. Public Citizen filed its petition in 2001, not long after Bayer pulled its statin drug Baycol (cerivastatin) off the market after mounting reports of patients dying from the condition while taking the medication. The ... Read More

UK advisors propose wider indication for cholesterol-lowering statins

The National Institute for Health and Care Excellence (NICE) has released a draft guidance on the management of high cholesterol for people with and without cardiovascular disease, as well as those with diabetes and chronic kidney disease. NICE, an agency that provides guidance for the United Kingdom’s National Health Service, recommends that high-intensity statin medications be given as a primary preventative treatment in patients with a 10 percent risk of cardiovascular disease over the next 10 years. Previously, the recommendation was for patients with a 20 percent risk of cardiovascular events over the next 10 years be treated with statins. ... Read More

Widely prescribed statins increase risk of type 2 diabetes

The cholesterol-lowering statin Crestor (rosuvastatin) is the top selling prescription medication for the 12-month period ending September 2013, according to a report from the research firm IMS Health. Crestor sold more than 23.7 million prescriptions raking in sales of $5.3 billion during that time period. Statins are commonly prescribed to lower cholesterol levels. They work by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver, which produce about 70 percent of total cholesterol in the body. Increased cholesterol levels have been associated with cardiovascular disease. Thus, statins are used to help ... Read More

Cholesterol-lowering statin medications can interfere with exercise

Regular physical activity is great for the body – helping to control weight, boost good HDL cholesterol, improve mood and lower the risk of diabetes and some cancers. But even with good exercise and healthy diet, cholesterol levels can be higher than desired. Cholesterol-lowering statins, such as Lipitor (atorvastatin), are often given to people in order to improve cholesterol levels and protect against heart disease. However, statins can lead to side effects that can make physical activity difficult. A study published in the Journal of the American College of Cardiology showed that the statin Zocor (simvastatin) prevented exercisers from reaching ... Read More

Discontinuing use of cholesterol-lowering Lipitor linked to Parkinson’s disease

Cholesterol-lowering statins, which include the widely prescribed Lipitor, were once thought to be wonder drugs because of their ability to protect against cardiovascular disease. However, new studies have raised concerns about the safety of the drugs and whether they may put users at greater risk for other health problems. Recent studies have identified a possible link between the use of statin medications and the development of type 2 diabetes. The risk was greater with Lipitor compared to other statins. Data from a University of Massachusetts study also showed that postmenopausal women who took Lipitor, particularly those with a body mass ... Read More

Cholesterol-lowering drug Lipitor associated with risk of developing type 2 diabetes

Cholesterol-lowering drugs may increase the chances of developing type 2 diabetes, according to a large Canadian study. The risk is grater for patients taking Lipitor (atorvastatin), Crestor (rosuvastatin), and Zocor (simvastatin). All three drugs are in a class of medications known as statins. They lower cholesterol by inhibiting the enzyme HMG-CoA reductace, which plays a central role in the production of cholesterol in the liver. Elevated cholesterol levels have been associated with cardiovascular diseases, and statins are used to help prevent these diseases. Statins have been effective in lowering cholesterol but they do carry adverse events, specifically muscle damage. The ... Read More

Statins tied to increased risk for type 2 diabetes

Statin drugs used to prevent heart attacks may increase the risk of type 2 diabetes, according to a new study published in the British Medical Journal. Statins are a class of drugs commonly prescribed to help lower “bad” cholesterol in the blood to reduce the chances of heart attack or stroke. The study, conducted by researchers in Canada, compared the incidence of diabetes between 1.5 million people older than age 66 taking various statins. They found that the strongest statins could increase the risk of type 2 diabetes by 22 percent compared to less potent drugs. Atorvastatin, known by the ... Read More

Researchers find dozens more prescription drugs can be deadly with grapefruit

Grapefruit, an excellent source of vitamin C, beta-carotene, lycopene, and other vital nutrients, becomes extremely toxic when mixed with a growing number of prescription drugs, according to a new Canadian study. Dozens of widely used drugs interact with compounds in the popular citrus fruit, triggering serious complications and even death. “The number of drugs on the market with the potential to produce serious adverse and in many cases life-threatening effects when combined with grapefruit has markedly increased over the past few years from 17 to 43 in four years,” lead researcher David Bailey of the Lawson Health Research Institute in ... Read More

FDA rejects Merck’s new combo cholesterol drug

Merck & Co. will have to provide more data on its experimental cholesterol-lowering drug cocktail before the Food and Drug Administration (FDA) will allow it to be sold in the United States. The drug, known only as MK-0653C, is designed to fight high cholesterol in two different ways to reduce the risk of heart attack and stroke. Merck’s new drug contains a generic version of the statin Lipitor, the top selling drug of all time. Known chemically as atorvastatin, Lipitor works to reduce the amount of cholesterol naturally produced in the liver. MK-0653C also contains Zetia, known as simvastatin, a ... Read More