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SSRI 136 articles

SSRIs possibly linked to serious drug reaction

The Food and Drug Administration (FDA) is evaluating whether it should take some form of regulatory action after receiving reports of a condition called drug reaction with eosinophilia and systemic symptoms, or DRESS, in patients taking a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs. DRESS syndrome is caused by exposure to certain medications and may result in a rash, fever, inflammation of internal organs, lymphadenopathy, and characteristic hematologic abnormalities such as eosinophilia, thrombocytopenia, and atypical lymphocytosis. SSRIs are used to treat depression, seasonal affective disorder (SAD), general anxiety disorder, obsessive-compulsive disorder, and in some cases smoking cessation, ... Read More

Effexor linked to accelerated bone loss

The antidepressant Effexor has been linked to accelerated bone loss, according to a study published in the Journal of the American Geriatrics Society. Effexor contains the active ingredient venlafaxine. It is used to treat depression, generalized anxiety disorder, panic disorder, and social anxiety disorder. It is in a class of antidepressants called serotonin-norepinephrine reuptake inhibitors, or SNRIs. The medication has been associated with increased levels of a bone reabsorption marker (CTX) as well as decreased levels of a bone formation marker (P1NP). Researchers from the Washington University School of Medicine in St. Louis conducted an open-label treatment study involving 168 ... Read More

FDA evaluating link between antidepressants and ‘broken heart syndrome’

Antidepressants may break your heart … or at least that’s what the Food and Drug Administration (FDA) aims to find out. In its latest quarterly filing of Potential Signals of Serious Risks/New Safety Information identified through its adverse event database for April to June 2016, the FDA says it is reviewing cases of stress cardiomyopathy – known as the “broken heart syndrome” – to determine whether regulatory action – such as a new warning – is needed. Stress cardiomyopathy is also referred to as takotsubo cardiomyopathy and apical ballooning syndrome. It is a condition in which intense emotional or physical ... Read More

SSRIs during pregnancy linked to dyslexia, speech disorders

Children born to women who took a class of antidepressants while pregnant are at greater risk of having a language disorder, such as dyslexia, according to a new study published in JAMA Psychiatry. The risk is relatively low, explained Dr. Alan Brown, lead author of the study and professor of psychiatry and epidemiology at Columbia University Medical Center. Children whose mothers did not take an antidepressant while pregnant have about a 1 percent risk of being diagnosed with a speech or language disorder compared to 1.37 of children who were born to mothers who did take the drugs. But the ... Read More

Preeclampsia linked to increased risk of infant heart defects

Babies born to women with a pregnancy complication known as preeclampsia are at greater risk of having a heart defect, a new study shows. Preeclampsia is a characterized by high blood pressure and signs of damage to another organ system, generally the kidneys, in women who are at least 20 weeks pregnant. The condition can be life threatening to both the mother and the infant, and the only cure is delivery of the baby. This can result in premature birth, which can result in various complications for the newborn. The study, conducted by researchers at the University of Montreal Hospital ... Read More

Study links antidepressant use during pregnancy to serious birth defect

Pregnant women who take antidepressants had a small but statistically significant increased risk of their babies being born with a life threatening lung defect called persistent pulmonary hypertension of the newborn, or PPHN, according to a new population-based study. PPHN is a condition in which a newborn baby’s circulation changes back to the circulation of a fetus, where much of the blood flow bypasses the lungs. When blood is shunted away from the baby’s lungs, it is difficult for the lungs to exchange oxygen and carbon dioxide, resulting in low blood oxygen levels. This can be serious and cause organ ... Read More

FDA advisors raise concerns over ‘female Viagra’ during third review

The Food and Drug Administration (FDA), for the third time, is raising concerns about safety risks with the so-called female Viagra drug currently under review. The agency says the drug can cause women to faint and accidentally injure themselves, especially if the medication is taken with alcohol. The concerns were published on the FDA’s website two days before an FDA advisory panel will decide whether to recommend approval of the drug or, for the third time, reject it based on concerns. The FDA is not required to follow the recommendations of its advisory panels, but it usually does. The drug ... Read More

Zoloft linked to significant increase in coronary plaque

Laboratory monkeys treated with the antidepressant Zoloft were six times more likely to have a type of coronary plaque called atherosclerosis plaque in their coronary arteries, the primary cause of heart attacks, according to a new study published in the journal Psychosomatic Medicine. It has been widely known for years that depression and heart disease go hand-in-hand. Researchers at Wake Forest Baptist Medical Center wondered if treating depression would reduce heart disease risk. For the study, they fed 42 female monkeys a Western-like diet containing fat and cholesterol for 18 months. During this pre-treatment phase, depressive behavior in the primates was ... Read More

Judge OKs new expert in Zoloft birth defects lawsuit

U.S. District Judge Synthia Rufe ruled that plaintiffs in a multidistrict litigation alleging Zoloft birth defects can introduce a new expert to testify on the association between the antidepressant and cardiac injuries after three others presented by plaintiffs had been excluded by the court for not following proper research methodology. Plaintiffs suing Pfizer will present as a general causation expert witness Nicholas Jewell, a professor at the University of California, Berkeley’s School of Public Health and its statistics department. Judge Rufe ruled that the evidence Jewell is expected to introduce regarding heart risks with Zoloft are of “critical importance” to the plaintiffs’ ... Read More

Mental health groups ask FDA to remove black box warning for suicide risk from antidepressants

Mental health experts are petitioning the Food and Drug Administration (FDA) to remove its severest warning involving suicidal thoughts from the safety labels on all antidepressants because the warning has resulted in a 33 percent increase in suicide attempts, and has scared away some patients who may benefit from the medication. In 2004, the FDA placed a black box warning, its most serious kind, on all categories of antidepressants, indicating that there is an increased suicide risk in children and adolescents treated with the drugs. Two years later, the FDA extended the warning to young adults to age 25 and recommended ... Read More