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stroke 221 articles

Class of painkillers linked to increased risk of death from stroke

brain

A class of anti-inflammatory drug used to relieve pain due to inflammation have been linked to an increased risk of death from stroke, according to a new study published online in the journal Neurology. Cyclooygenase-2 (COX-2) inhibitors are a form of non-steroidal anti-inflammatory drugs (NSAIDS) that directly target COX-2, an enzyme responsible for inflammation and pain. They are often used to treat pain after surgery as well as arthritis pain, menstrual cramps, and pain from noncancerous colon polyps. Currently marketed drugs in this class include the brand names Bextra (valdecoxib) and Celebrex (celecoxib), and also include the painkiller Vioxx (rofecoxib), which ... Read More

Lawsuit filed against Pfizer related to testosterone replacement drug

Depo testosterone

Pfizer’s testosterone replacement treatment Depo-Testosterone has become the subject of lawsuits questioning the safety and efficacy of the drugs after reports of heart attacks, strokes and blood clots in patients treated with the hormone. The lawsuit filed on behalf of Alvaro Roman Gutierrez alleges that Pfizer and its unit Pharmacia & Upjohn Co. LLC, conducted a “disease mongering” campaign to exaggerate the problem of low testosterone levels in men in order to boost sales of Depo-Testosterone. Gutierrez claims that Pfizer and Pharmacia & Upjohn spent millions of dollars to promote its drug to consumers and, along with other drug companies not ... Read More

New testosterone treatment in development carries fewer side effects

androgel-pump

Testosterone levels in men typically drop as a man ages, but when it drops too low it signals a possible problem. In many cases the drop can be associated with obesity, diabetes and circulatory disease. Low testosterone levels can result in symptoms such as low libido, loss of muscle mass, increased body fat, and depression. Regardless the cause, many doctors prescribe testosterone replacement therapies, such as AndroGel, Axiron and Testim, to treat the condition. However, recent studies have shown that testosterone therapy can increase the risk of heart attack, stroke or death. The drugs can also be expensive, and after ... Read More

Young adults who were treated with growth hormones as children may be at greater risk for stroke

children-smiling for WEB

People who received growth hormones as children to treat short stature or hormone deficiency should be aware that they are at an increased risk of stroke caused by burst blood vessels when they become young adults, a team of French and British researchers say. The warning is based on findings from a study published in this week’s issue of the journal Neurology, and applies also to people who misuse the growth hormones to improve athletic performance, for body building and other “questionable reasons.” Growth hormones were approved in the United States in the mid-1980s to treat pituitary gland problems and to ... Read More

Statin side effects may outweigh benefits for most people

lipitor

An estimated five out of 100 people taking cholesterol-lowering statins after a heart attack will cheat death, another heart attack, or a stroke during the five years after having a heart attack. However, it is difficult to identify which five individuals will benefit from the drugs, says Dr. Janice B. Schwartz, a professor of medicine and bioengineering and therapeutic sciences at University of California San Francisco. Thus, statin side effects should be carefully weighed by patients who are candidates of the new statin guidelines. “There is no question that the medications can cause unwanted side effects – both directly from ... Read More

Man says his stroke was caused by AndroGel testosterone treatment

androgel-pump

Ed Downes’ stroke seemed to come out of nowhere. Ed, who was in his upper 40s at the time, was taking medication for hypertension and attention deficit disorder (ADD), but was otherwise healthy. When he began to lose interest in sex and his energy level plummeted, he, like hundreds of thousands of other men, followed the advice of a drug company’s television commercial and had a “conversation with his doctor” to see if he was suffering from low testosterone, or, as the advertisement called it, “Low T.” Ed was prescribed AndroGel, a testosterone replacement gel, which he took for two years. ... Read More

Investigational drug helps to dramatically lower cholesterol levels in statin users

lipitor

A new injectable drug can help further reduce cholesterol levels in people taking statin medications, according to a new study published in the Journal of the American Medical Association. The drug evolocumab, a so-called human monoclonal antibody, works to improve the body’s ability to remove cholesterol from the blood. When paired with cholesterol-lowering statins, the drug offered a 63 to 75 percent decrease in “bad” (LDL) cholesterol. A phase 3 clinical trial on the drug involved more than 2,000 people from 198 sites in 17 countries. In the course of 12 weeks, patients were randomly assigned to take evolocumab or another ... Read More

FDA questions value of aspirin therapy for heart attack prevention

aspirin - FDA image

The Food and Drug Administration (FDA) last week denied a request by German drug maker Bayer AG to change the label on packages of its aspirin to promote the benefits of regular aspirin therapy to ward off first heart attack or stroke in people who have never had cardiovascular problems. Now the agency is questioning whether the treatment carries any value to those with no heart issues and whether taking a daily aspirin may actually put these individuals at risk for potentially serious side effects. Aspirin therapy is often recommended for people with cardiovascular disease because it reduces the clotting ... Read More

Physicians question safety of testosterone replacement therapy

Axiron

Increasing numbers of physicians are questioning whether testosterone replacement therapy to boost libido, muscle mass and mood may do more harm than good. Recent studies have linked testosterone therapy to an increased risk of heart attack, stroke and death. News of the study results rang loudly throughout America, where nearly 3 percent of men older than 40 are using prescription testosterone supplements as a “fountain of youth.” And they didn’t come blindly to their doctors in search of a cure. Many were swayed by heavy marketing campaigns waged by drug companies concocting a disorder they called “Low T,” and urging men ... Read More

Type 2 diabetes may shrink brain tissue, lead to cognitive disorders

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Long-term type 2 diabetes may shrink gray matter, the portion of the brain responsible for memory, emotions, decision-making and self control, according to a new study published in the journal Radiology. For each decade a person has diabetes, his brain looks about two years older than a non-diabetic, researchers found. For the study, researchers with the University of Pennsylvania analyzed MRI scans to evaluate brain structure of more than 600 patients with type 2 diabetes. They were surprised to find that diabetes was not linked to just the damaging effect of the tiny blood vessels in the brain, but by ... Read More