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stroke 225 articles

Doctors reluctant to prescribe testosterone therapy

Doctors are more reluctant to prescribe testosterone therapy to male patients than they were years ago, according to an international survey of endocrinologists. The study was designed to document current practices in the approach to low testosterone in older men. “Given that recommendations are based on low-level evidence, we hypothesized that there would be a wide variety in clinical practice patterns,” researchers wrote. The web-based survey was completed by 943 physicians from North America, Europe, Oceania, Latin America, the Caribbean, the Middle East, Asia and Africa. “There was a wide variability in clinical practice patterns,” researchers wrote. “A total of ... Read More

First-time users of testosterone replacement treatments are at greater risk of heart attack

Men using testosterone replacement treatments are at greater risk of suffering a heart attack during the first 90 days of treatment than men who have been on the hormone replacement for more than four months. They were also at greater risk of heart attack compared to men who had used the treatment and discontinued use, according to a new study published in the journal Pharmacotherapy. The study involved data from the IMS LikeLink database for new-onset heart attacks in men ages 45 to 80 who had filled at least one prescription for testosterone replacement therapy. Researchers looked at current users ... Read More

Europe’s drug authority considers heart risks with testosterone replacement therapy

European drug regulators are weighing whether the benefits of testosterone replacement therapy are worth the risk of life threatening cardiovascular events. Testosterone therapy, such as AbbVie’s AndroGel, is approved in both the United States and Europe for the treatment of hypogondaism, a condition in which the body does not produce enough testosterone. This can cause symptoms such as low sex drive and muscle loss. In recent years, makers of testosterone treatments have heavily marketed the drugs directly to consumers, asking men if they suffer from what they deem symptoms of “Low-T” – weight gain, fatigue, and general grumpiness. The campaign was ... Read More

Class of painkillers linked to increased risk of death from stroke

A class of anti-inflammatory drug used to relieve pain due to inflammation have been linked to an increased risk of death from stroke, according to a new study published online in the journal Neurology. Cyclooygenase-2 (COX-2) inhibitors are a form of non-steroidal anti-inflammatory drugs (NSAIDS) that directly target COX-2, an enzyme responsible for inflammation and pain. They are often used to treat pain after surgery as well as arthritis pain, menstrual cramps, and pain from noncancerous colon polyps. Currently marketed drugs in this class include the brand names Bextra (valdecoxib) and Celebrex (celecoxib), and also include the painkiller Vioxx (rofecoxib), which ... Read More

Lawsuit filed against Pfizer related to testosterone replacement drug

Pfizer’s testosterone replacement treatment Depo-Testosterone has become the subject of lawsuits questioning the safety and efficacy of the drugs after reports of heart attacks, strokes and blood clots in patients treated with the hormone. The lawsuit filed on behalf of Alvaro Roman Gutierrez alleges that Pfizer and its unit Pharmacia & Upjohn Co. LLC, conducted a “disease mongering” campaign to exaggerate the problem of low testosterone levels in men in order to boost sales of Depo-Testosterone. Gutierrez claims that Pfizer and Pharmacia & Upjohn spent millions of dollars to promote its drug to consumers and, along with other drug companies not ... Read More

New testosterone treatment in development carries fewer side effects

Testosterone levels in men typically drop as a man ages, but when it drops too low it signals a possible problem. In many cases the drop can be associated with obesity, diabetes and circulatory disease. Low testosterone levels can result in symptoms such as low libido, loss of muscle mass, increased body fat, and depression. Regardless the cause, many doctors prescribe testosterone replacement therapies, such as AndroGel, Axiron and Testim, to treat the condition. However, recent studies have shown that testosterone therapy can increase the risk of heart attack, stroke or death. The drugs can also be expensive, and after ... Read More

Young adults who were treated with growth hormones as children may be at greater risk for stroke

People who received growth hormones as children to treat short stature or hormone deficiency should be aware that they are at an increased risk of stroke caused by burst blood vessels when they become young adults, a team of French and British researchers say. The warning is based on findings from a study published in this week’s issue of the journal Neurology, and applies also to people who misuse the growth hormones to improve athletic performance, for body building and other “questionable reasons.” Growth hormones were approved in the United States in the mid-1980s to treat pituitary gland problems and to ... Read More

Statin side effects may outweigh benefits for most people

An estimated five out of 100 people taking cholesterol-lowering statins after a heart attack will cheat death, another heart attack, or a stroke during the five years after having a heart attack. However, it is difficult to identify which five individuals will benefit from the drugs, says Dr. Janice B. Schwartz, a professor of medicine and bioengineering and therapeutic sciences at University of California San Francisco. Thus, statin side effects should be carefully weighed by patients who are candidates of the new statin guidelines. “There is no question that the medications can cause unwanted side effects – both directly from ... Read More

Man says his stroke was caused by AndroGel testosterone treatment

Ed Downes’ stroke seemed to come out of nowhere. Ed, who was in his upper 40s at the time, was taking medication for hypertension and attention deficit disorder (ADD), but was otherwise healthy. When he began to lose interest in sex and his energy level plummeted, he, like hundreds of thousands of other men, followed the advice of a drug company’s television commercial and had a “conversation with his doctor” to see if he was suffering from low testosterone, or, as the advertisement called it, “Low T.” Ed was prescribed AndroGel, a testosterone replacement gel, which he took for two years. ... Read More

Investigational drug helps to dramatically lower cholesterol levels in statin users

A new injectable drug can help further reduce cholesterol levels in people taking statin medications, according to a new study published in the Journal of the American Medical Association. The drug evolocumab, a so-called human monoclonal antibody, works to improve the body’s ability to remove cholesterol from the blood. When paired with cholesterol-lowering statins, the drug offered a 63 to 75 percent decrease in “bad” (LDL) cholesterol. A phase 3 clinical trial on the drug involved more than 2,000 people from 198 sites in 17 countries. In the course of 12 weeks, patients were randomly assigned to take evolocumab or another ... Read More