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Alabama man files testosterone side effects lawsuit after suffering stroke

An Alabama man has filed a lawsuit against the makers of the testosterone replacement treatment Testim, claiming the drug caused him to have a stroke. Robert Hoehl, 64, had no history of cerebrovascular disease or neurological impairments when he began the hormone therapy in the fall of 2011. Less than a year later, he had a stroke. He immediately stopped taking Testim. Doctors noticed he had elevated hematocrit levels, a condition that can increase the risk of blood clots, heart disease and stroke. Hoehl’s blood levels were checked on a regular basis. Within months after quitting Testim, his hematocrit levels ... Read More

Philadelphia man claims Testim testosterone treatment gave him a heart attack

A 67-year-old Philadelphia man with no history of cardiovascular problems has filed a lawsuit against the makers of his testosterone replacement product claiming the drug caused him to suffer a heart attack. The lawsuit states that the injury was caused by the “exogenously administered testosterone-containing Testim,” a prescription drug made by Auxilium Pharmaceuticals and GlaxoSmithKline. Edwin Rios had been using Testim for a year when he had the heart attack. Testosterone replacement products are designed to boost the hormone’s levels in men who are experiencing symptoms of low testosterone such as weight gain, mood swings, and low libido. Testim was ... Read More

Controversy surrounds upcoming FDA decision on long-acting testosterone drug

The Food and Drug Administration (FDA) is expected to decide this week the fate of a long-acting testosterone product made by Endo Health Solutions, Inc. Aveed, indicated to boost testosterone in men with low levels of the hormone, has been rejected by the agency twice before based on health risks. Aveed, sold in other countries under the brand name Nebido, received mixed reactions from FDA advisors last year. The panel was split 9-9 on whether to recommend approval of the drug. Some advisors said the drug offers a valuable alternative to existing shorter-acting products, such as AndroGel, Testim and Axiron. ... Read More

Public Citizen urges FDA to add warnings of heart attack, stroke, death to testosterone treatments

Consumer advocacy group Public Citizen is petitioning the Food and Drug Administration (FDA) to require manufacturers of testosterone treatments to add black box warnings on the labels about the increased risk of heart attacks, stroke and death in men who use the treatment. Black box warnings are the strongest given by drug regulators and signify that medical studies indicate that a particular drug carries a significant risk of serious or even life-threatening adverse events. Testosterone supplements, including AndroGel, Testim and Axiron, are approved by the FDA to treat hypogonadism, a medical condition in which the testes produce little to no testosterone. ... Read More

Does testosterone therapy pose heart risks for women?

You probably wouldn’t know it from the male-targeted advertisements pushing hormone supplements to boost “Low T,” but testosterone therapy can provide similar benefits for women. The question is, does it also carry the same risk of heart attacks, strokes and death in women as it does for men? Testosterone is considered the male hormone, responsible for the maturation of the testis and prostate as well as the development of sexual characteristics such as increased muscle, bone mass and body hair. In general, adult men have about 7-8 times more testosterone pumping through their bodies than adult females. Estrogen, considered the ... Read More

Endocrine Society says older men should be made aware of heart risks with testosterone therapy

Older men who are considering testosterone replacement therapy to boost their libido, increase muscle mass and fight fatigue should first talk to their doctors about their increased risk of heart attacks, strokes and death when taking the supplements, according to the Endocrine Society. Testosterone therapy is approved by the Food and Drug Administration (FDA) to treat a condition known as hypogonadism, which occurs when a man’s testicles do not produce enough testosterone. It is common as men age for their testosterone levels to drop, and many men do not experience or are not bothered by the symptoms. However, drug companies ... Read More

Endocrine Society calls for larger assessment of risks with testosterone therapy

Just days after the Food and Drug Administration (FDA) announced it was investigating the safety of testosterone replacement treatments, the U.S. Endocrine Society called for a fuller assessment of the risks and benefits associated with the hormone treatment. The actions follow two new studies that raised serious concerns about the risks of testosterone therapy in older men. One study showed that men who used testosterone supplements were significantly more likely to have a heart attack in the first 90 days after starting the treatment. A second study found that older men who used the treatment were nearly 30 percent more ... Read More

Blood sugar increases with statins a concern for diabetics

Type 2 diabetes increases the risk of heart attacks and strokes. Many patients with diabetes also have elevated cholesterol levels – a condition that can also increase cardiovascular risks – which is often managed by cholesterol-lowering statin medications. However, recent studies show that statin therapy can increase blood sugar levels. Statin medications, such as the widely prescribed Lipitor, reduce the number of cardiovascular events overall, but have also been shown to increase fasting blood glucose and HbA1c, a form of hemoglobin that is measured primarily to identify the average blood glucose concentration over a prolonged period of time. New studies ... Read More

Testosterone treatments can double, triple heart attack risk in men

Men who use testosterone replacement therapies have a “substantial” risk of having a heart attack, says Francisco Lopez-Jimenez, a Mayo Clinic researcher involved in a new study published in the journal PLOS One. The report is one of a series of new studies looking into the long-term effects of testosterone therapy, a treatment that has increased dramatically in popularity in recent years. The study involving 56,000 men found that older men using testosterone supplements were twice as likely to have a heart attack, and younger men with heart disease were nearly three times as likely to have heart problems. “That’s the ... Read More

New blood-filtering therapy can help reduce very high cholesterol levels

Cardiologists from the University of Rochester Medical Center are offering a new blood-cleansing treatment for people with extremely high cholesterol known as hypercholesterolemia. The filtering process is designed to remove excess cholesterol from the blood in an effort to reduce the risk of stroke or heart attack. “This new therapy offers a tremendous advance for patients with familial hypercholesterolemia, which is a genetic cause of very high cholesterol and relatively rare, but can be very dangerous because standard medications are ineffective in sufficiently lowering the cholesterol levels,” said Robert Block, M.D., M.P.H., a lipids expert and director of the URMC ... Read More