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toxic epidermal necrolysis 95 articles

High court upholds $140 million verdict involving Children’s Motrin injuries

The U.S. Supreme Court denied Johnson & Johnson’s petition to have a $140 million jury verdict reviewed in a failure-to-warn case involving a teenage girl who developed a serious skin reaction blamed on the company’s Children’s Motrin. Johnson & Johnson had argued that claims made by Samantha Reckis and her parents that the over-the-counter painkiller gave her a painful and blistering skin condition should have been preempted by the 2009 Supreme Court decision in Wyeth v. Levine, which found that drug makers cannot be held liable for not including a label that “clear evidence” indicates the FDA would not have ... Read More

McNeil denied appeal in $10 million Children’s Motrin verdict

The Pennsylvania Supreme Court refused to hear an appeal by Johnson & Johnson unit McNeil-PPC Inc., of a $10 million verdict levied against the company by the family of a girl who suffered a serious allergic reaction and blindness after taking Children’s Motrin as prescribed for fever. McNeil had petitioned the state high court to hear the case after its bid for appeal was rejected by the Pennsylvania Superior Court panel last September. The panel supported the lower court’s decision in July, which found the consumer health care company failed to warn that its over-the-counter medicine could cause the serious ... Read More

Woman suffers Stevens Johnson Syndrome, burning ‘from inside out’ after taking a friend’s medication

A young mother is fighting for her life after taking a friend’s prescription antibiotic and suffering an allergic reaction that doctors say is causing her to burn from the inside out. Yassmeen Castanada took the antibiotic on Thanksgiving to help ward off a sickness she felt coming on. But shortly afterward her eyes, nose and throat began to burn. She was rushed to the emergency room where her condition progressed. Within days, blisters covered her body and her skin began to peel off in sheets, causing excruciating pain and exposing her to life-threatening infection. The diagnosis – Stevens Johnson Syndrome ... Read More

McNeil loses appeal on $10 million Children’s Motrin judgment

Johnson & Johnson subsidiary McNeil-PPC failed to convince the Pennsylvania Superior Court to overturn a $10 million verdict alleging the company’s Children’s Motrin caused a girl to develop a life threatening condition that burned her skin and caused her to go blind. McNeil argued that there was no evidence to show that the company’s failure to warn consumers of the risk of the serious allergic reaction on the drug’s safety label led to the the girl’s injuries. Brianna Maya was 3 when her mother gave her Children’s Motrin over the course of four days to treat a fever and cough. ... Read More

Skin reaction warning added to Excedrin Migraine over-the-counter pain reliever

Safety labels of over-the-counter pain reliever Excedrin Migraine have been updated to include a warning for serious skin reactions, the Food and Drug Administration (FDA) announced. Symptoms of this allergic reaction include skin reddening, blisters and rash. Consumers who use this medicine and develop a skin reaction are advised to stop use and seek medical attention right away. Excedrine Migraine contains 250 mg acetaminophen, 250 mg aspirin and 65 mg caffeine. This combination of drugs is used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, and nasal congestion. In 2013, ... Read More

Serious skin reactions linked to anti-seizure drug Onfi (clobazam)

The anti-seizure drug Onfi (clobazam) has been linked to rare but serious skin reactions that have caused permanent injuries and death, the Food and Drug Administration (FDA) warned. New warnings on the drug’s label and patient guide have been updated to describe these serious skin reactions. The skin reactions are Stephens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN), and can occur at any time during treatment with Onfi. However, the likelihood of these reactions occurring is greater during the first eight weeks of treatment or when the drug is stopped and then restarted. All cases of SJS and TEN ... Read More

FDA warns of rare but serious skin reactions with painkiller acetaminophen

The widely used fever reducer and painkiller acetaminophen can cause rare but serious and potentially life threatening skin reactions, warns the Food and Drug Administration (FDA). Acetaminophen has been available for decades and is available both by prescription and over-the-counter. Tylenol is one brand name of the pain reliever, but it is also available in generic versions and as well as in combination with other medicines including opioids for pain, and medicines to treat colds, coughs, allergy, headaches, and sleeplessness. Skin reactions to acetaminophen are rare but include three serious skin diseases with symptoms that range from rashes and blisters to widespread ... Read More

Johnson and Johnson ordered to pay $63 million to girl who suffered severe reaction to Children’s Motrin

Consumer health product giant Johnson & Johnson has been ordered to pay $63 million plus interest to a Massachusetts teenager who suffered a serious skin reaction and lingering medical complications after taking the pain reliever Children’s Motrin. Samantha Reckis was given the ibuprofen when she was 7, an over-the-counter medicine she had taken previously without experiencing ill effects. But this time, Samantha suffered a severe reaction. Her throat, mouth, eyes, esophagus, intestinal tract, respiratory system and reproductive system became inflamed, and her doctors had to put Samantha into a coma to treat her. She was diagnosed with toxic epidermal necrolysis ... Read More

New warnings on anti-epilepsy drug Keppra

New warnings and precautions have been added to the safety label of the anti-epileptic drug Keppra (levetiracetam), alerting patients to possible adverse reactions ranging from psychiatric problems to serious skin reactions. Keppra is an anti-convulsant medication commonly used to treat patients who suffer from seizures related to epilepsy and other disorders. The medication comes in both brand-name and generic versions and is sold in both tablet and oral solution form. The new safety labels were approved last month by the Food and Drug Administration (FDA). New warnings on Keppra include the risk for psychiatric symptoms including aggression, agitation, anger, anxiety, ... Read More

Anti-seizure drugs carry new black box warning

Two drugs used to control types of seizures now carry the Food and Drug Administration’s strongest warning for severe hypotension and cardiac arrhythmias. The drugs also carry a new warning for  serious skin disorders including the potentially fatal Stevens Johnson Syndrome (SJS) and the more severe form of the disease, toxic epidermal necrolysis (TEN). Cerebyx (fosphenytoin sodium) Injection and Dilantin (phenytoin) are anticonvulsant drugs that work in the brain to block or slow down the spread of seizure activity. The cardiovascular risk with these drugs is associated with rapid infusion. The rate of intravenous administration of Cerebyx should not exceed ... Read More