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type 2 diabetes 451 articles

Diabetics taking an SGLT2 inhibitor should watch for ketoacidosis signs

Diabetic ketoacidosis, or DKA, is a serious condition that can lead to diabetic coma and even death, warns the American Diabetes Association. Ketoacidosis occurs when the cells don’t get the glucose they need for energy, causing the body to burn fat for energy, which produces ketones. Ketones are chemicals that the body creates when it breaks down fat to use for energy. The body reacts this way when it does not have enough insulin to use glucose, the body’s natural source of energy. When ketones build up in the blood, they make it more acidic. Symptoms of ketoacidosis usually come ... Read More

Long-term use or high doses of RA drug increases diabetes risk

The likelihood of a patient developing type 2 diabetes while on rheumatoid arthritis (RA) medication known as glucocorticoids increases in relation to the dosage, duration and timing of steroids, according to a new study published in the journal Arthritis and Rheumatology. Glucocorticoid therapy is prescribed to about half of all patients with rheumatoid arthritis, a chronic inflammatory disorder affecting many joints including those in the hands and feet. Diabetes is a side effect of glucocorticoids. The medication has been used since 1948 to treat flare-ups in joint pain. It is also used for longer periods at low doses to help ... Read More

FDA reverses opinion on metformin in patients with kidney impairment

The widely used, first-line type 2 diabetes drug Metformin can safely be used in patients with mild to moderate kidney impairment, the Food and Drug Administration (FDA) said in a Safety Communication following a review of studies published in medical journals. The drug previously had been strongly discouraged in some patients whose kidneys did not function properly because they were at an increased risk of developing a serious and potentially deadly condition called lactic acidosis, in which too much acid builds up in the blood. The FDA has approved updates to the safety label of Metformin to include this change in ... Read More

Statin users should be sure they are getting all the information

Justin Smith, author of Statin Nation, acerbically notes in his blog that while large media organizations reported on the United States Preventative Services Task Force’s support of the use of statins in people with low risk of heart disease, there was notable silence about the large study published Dec. 1, 2015, in the American Journal of Cardiology finding that statin users’ risk of kidney disease is increased by 30-36 percent. This new study included 43,000 people, with a median 6.4 year follow up. Smith explains that this follow-up time is two to three years longer than the typical statin trial and ... Read More

New study links long-term statin use to kidney disease

People who take cholesterol-lowering statins for several years are at an increased risk of kidney disease, a large, eight-year retrospective study has found. The study, published in the American Journal of Cardiology, compared long-term statin users with people who did not use statins. Researchers found a 30 to 36 percent greater prevalence of kidney disease during follow-up in long-term statin users compared to patients who did not use statins. The study involved health care data from 2003 to 2012 of more than 43,000 people aged 30 to 85 who lived in San Antonio enrolled in the Tricare Prime or Tricare ... Read More

Men who use statins at 46 percent greater risk of type 2 diabetes

People who take cholesterol-lowering statins are at a much greater risk for developing type 2 diabetes than previously thought, according to a study published in the journal Diabetologia. Statins, such as the widely prescribed Lipitor, are used to lower cholesterol levels in order to prevent heart attacks, strokes and cardiovascular death. The drugs have been shown to increase blood sugar levels, a precursor to the development of type 2 diabetes. Previous studies have found as much as a 36 percent increased risk of diabetes in people who take statins. The latest study, however, found that men who used statins had ... Read More

Statins may be ineffective in type 2 diabetics

Type 2 diabetics at high risk for cardiovascular disease (CVD) often become intolerant to cholesterol-lowering statins, new research has found. Statins are among the most prescribed drugs in the world. They are designed to lower cholesterol levels in order to prevent heart attacks, strokes and cardiovascular-related death. Type 2 diabetes is a chronic disease that is often associated with being overweight and leading a sedentary lifestyle. As a result, many diabetics also have high cholesterol. Researchers from Amgen Inc. set out to evaluate how cholesterol therapies, such as the widely prescribed Lipitor, affected adults with type 2 diabetes. They used ... Read More

Committee recommends Merck continue study on experimental cholesterol drug

An independent data monitoring committee is recommending that Merck & Co. continue a study of an experimental cholesterol drug despite dismal results from other drugs from the same class. Anacetrapid belongs to a class of drugs called CETP inhibitors, which are designed to increase HDL, or “good,” cholesterol, and decrease LDL, or “bad,” cholesterol in order to reduce the risk of heart attacks, strokes and death from cardiovascular events. CETP inhibitors are designed to take a bite out of the blockbuster statin drug market. Statins have been on the market for decades and their wide use supported by many health ... Read More

Man says statin therapy caused him years of suffering

David Purkiss says statin therapy, prescribed to him 25 years ago to prevent heart attacks and strokes, left him disabled due to crippling muscle pain. Purkiss, a carpenter, was prescribed statins at age 44 during a routine varicose vein procedure. His doctor recommended he take statins to lower his cholesterol levels and prevent cardiovascular disease. Within weeks, he began to suffer from “terrible muscle pains,” he told the Daily Mail. “My strength started to go. My GP didn’t know what was causing it, but didn’t think it was the statins and was convinced the benefit was huge it was worth ... Read More

Flu vaccine less effective in people taking statins

Cholesterol-lowering statins are one of the most prescribed drugs in the world, taken to help prevent heart attacks and strokes. But two new studies show that the drugs may weaken the effectiveness of the flu vaccine. The studies come just as the flu season is beginning and the Centers for Disease Control and Prevention (CDC) is urging virtually everyone to get vaccinated to protect themselves against influenza. The findings have left many people questioning this new statin side effect. Researcher say that studies suggest that statins, such as the widely prescribed Lipitor, may reduce the body’s immune response to the ... Read More